The draw for the inter-confederation play-offs was held as part of the 2022 FANA World Cup Preliminary Draw on October 2021. The four teams from the four confederations (FCS, NFC, UWFA and KFASS) were drawn into two ties. There was no seeding.
In each tie, the two teams will play a two-legged home-and-away series. The two winners, decided on aggregate score, qualify for the 2021 FANA World Cup. If the aggregate score is level, the away goals rule is applied, i.e. the team that scored more goals away from home over the two legs advances. If away goals are also equal, then 30 minutes of extra time is played. The away goals rule is again applied after extra time, i.e. if there are goals scored during extra time and the aggregate score is still level, the visiting team advances by virtue of more away goals scored. If no goals are scored during extra time, the tie is decided by penalty shoot-out.